DRU Cymru Studies - Cardiff & Vale University

  • Title: A pilot study to investigate the association between antibiotic use and incidence of antibiotic-resistant Diabetic Foot Ulcer (DFU)
    Acronym: AMR bacteria in diabetic foot ulcers
    Recruitment Site: University Hospital of Wales
    Investigator: Dr J Lewis
    Contact Details: 

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  • Title: A Pragmatic Randomized Trial to Evaluate the Comparative Effectiveness Between Dapagliflozin and Standard of Care in Type 2 Diabetes Patients
    Acronym: The DECIDE Study
    Recruitment Site: Court Road Surgery
    Investigator: Dr R Hardwick
    Contact Details: 

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  • Title: A study to optimise methods of monitoring the immune response to Peptide Immunotherapy in Type 1 diabetes
    Acronym: Peptidia Lymph Node Monitor
    Recruitment Site: University Hospital of Wales
    Investigator: Prof C Dayan
    Contact Details: 

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  • Title: ADDRESS C-PEPTIDE: Validation and assessment of urine C-peptide to creatinine ratio as a measure of beta cell function in a multi-ethnic new-onset type 1 diabetes cohort
    Acronym: ADDRESS C-PEPTIDE
    Recruitment Site: University Hospital of Wales
    Investigator: Prof C Dayan
    Contact Details: 

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  • Title: An incident and high risk type 1 diabetes research cohort - After Diagnosis Diabetes REsearch Support System-2 (ADDRESS-2)
    Acronym: ADDRESS-2 (DRN 552)
    Recruitment Site: University Hospital of Wales
    Investigator: Prof C Dayan
    Contact Details: 

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  • Title: Can the introduction of rapid and automatic Ankle Brachial Pressure and Pulse Volume measuring device into General Practice identify the presence of Peripheral Arterial Disease in cardiovascular risk groups?
    Acronym: Primary Care Screening for PAD in at risk groups
    Recruitment Site: Clifton Surgery; Llandaff North Medical Centre; Llandaff and Pentyrch Surgeries; Roath House Surgery; Waterfront Medical Centre; Whitchurch Village Surgery
    Investigator: Dr C Davies; Dr E Davies; Dr EJ Rees; Dr A Rothwell; Dr R Thomas; Dr C Walby
    Contact Details: 

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  • Title: Enhanced Epidermal Antigen Specific Immunotherapy trial-1 (EE-ASI-1): A Phase 1a study of gold nanoparticles administered intradermally by microneedles to deliver immunotherapy with a proinsulin derived peptide in Type 1 diabetes
    Acronym: EE-ASI-1
    Recruitment Site: University Hospital of Wales
    Investigator: Prof C Dayan
    Contact Details: 

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  • Title: Immune cell Studies in Type 1 Diabetes
    Acronym: ISTID
    Recruitment Site: University Hospital of Wales
    Investigator: Prof C Dayan
    Contact Details: 

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  • Title: Phenotyping the Brecon Cohort of childhood-onset Type 1 Diabetes to identify those at risk of adverse long-term outcomes who may in future merit immunotherapeutic intervention at diagnosis: a feasibility study
    Acronym: Phenotyping the Brecon Cohort
    Recruitment Site: University Hospital of Wales
    Investigator: Prof J Gregory
    Contact Details: 

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  • Title: StartRight: Getting the right classification and treatment from diagnosis in young adults with diabetes
    Acronym: StartRight Study
    Recruitment Site: University Hospital of Wales
    Investigator: Prof C Dayan
    Contact Details: 

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  • Title: T Cell studies in type 1 diabetes
    Acronym: T cell studies in T1D
    Recruitment Site: University Hospital of Wales
    Investigator: Prof C Dayan
    Contact Details: 

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  • Title: The role of habitual physical activity and sedentary time on cardiovascular health and metabolic control for children and adolescents with type 1 diabetes mellitus
    Acronym: 
    Recruitment Site: University Hospital of Wales
    Investigator: Prof J Gregory
    Contact Details: 

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  • Title: TriMaster: Randomised Double-Blind Crossover Study of a DPP4 Inhibitor, SGLT2 Inhibitor and Thiazolidinedione as Third Line Therapy in Patients With Type 2 Diabetes Who Have Suboptimal Glycaemic Control on Dual Therapy With Metformin and Sulphonylurea
    Acronym: TriMaster
    Recruitment Site: University Hospital of Wales
    Investigator: Dr H Bolusani
    Contact Details: 

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  • Title: 4222: Efficacy and long-term safety of oral semaglutide versus sitagliptin in subjects with type 2 diabetes mellitus. A 78-week, randomised, double-blind, double-dummy, active-controlled, parallel-group, multi-centre, multi-national, four-armed trial
    Acronym: Pioneer 3
    Recruitment Site: University Hospital of Wales
    Investigator: Prof C Dayan
    Contact Details: 

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  • Title: A multi-centre, prospective, non-interventional study of a basal insulin investigating the safety and effectiveness in a real world population with type 1 and 2 diabetes mellitus
    Acronym: DIAB 4026
    Recruitment Site: Ely Bridge Surgery
    Investigator: Dr J Wakeling
    Contact Details: 

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  • Title: A Phase I, Placebo Controlled, Double-Blind, Dose Escalation Clinical Trial to Evaluate the Safety and Immune Responses of IMCYSE's IMCY-0098 in Patients with Recent Onset Type 1 Diabetes
    Acronym: Phase 1 study of IMCY-0098 in Recent Onset Type 1 Diabetes
    Recruitment Site: University Hospital of Wales
    Investigator: Prof C Dayan
    Contact Details: 

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  • Title: A randomised controlled trial of continuous subcutaneous insulin infusion (CSII) compared to multiple daily injection (MDI) regimens on insulin in children and young people at diagnosis of type I diabetes mellitus (TIDM). (SCIPI)
    Acronym: SCIPI
    Recruitment Site: University Hospital of Wales
    Investigator: Prof J Gregory
    Contact Details: 

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  • Title: A randomised, double blind, placebo controlled multicentre trial, examining the effect of natrox on the rates of healing for chronic diabetic foot ulcers
    Acronym: DIAB 4383
    Recruitment Site: Cardiff University
    Investigator: 
    Contact Details: 

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  • Title: A Randomized, Double-blind, Event-driven, Placebo-controlled, Multicenter Study of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Subjects With Type 2 Diabetes Mellitus and Diabetic Nephropathy
    Acronym: DIAB 3286 (The CREDENCE Trial)
    Recruitment Site: Ely Bridge Surgery; The Waterfront Surgery; University Hospital of Wales
    Investigator: Dr E Davies; Dr A Roberts; Dr J Wakeling
    Contact Details: 

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  • Title: A study to evaluate the effect of a digital disease management tool in patients with type 2 diabetes mellitus
    Acronym: DIAB 5013
    Recruitment Site: Llanderyn Medical Centre; University Hospital of Wales
    Investigator: Dr A Roberts; Dr J Shearing
    Contact Details: 

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  • Title: A Study To Optimise Methods of Monitoring the Immune Response to Intradermally Delivered Antigens Using Draining Lymph Node Aspiration
    Acronym: PPD MONITOR
    Recruitment Site: University Hospital of Wales
    Investigator: Dr D Tatovic
    Contact Details: 

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  • Title: Access to Transplantation and Transplant Outcome Measures
    Acronym: ATTOM version 1
    Recruitment Site: University Hospital of Wales
    Investigator: Dr S Griffin
    Contact Details: 

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  • Title: Albiglutide versus Placebo in Subjects with new-onset type 1 diabetes mellitus
    Acronym: DRN 3266 (Albiglutide versus placebo in type 1 diabetes)
    Recruitment Site: University Hospital of Wales
    Investigator: Prof C Dayan
    Contact Details: 

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  • Title: ASCEND: A randomised 2x2 factorial study of aspirin versus placebo, and omega-3 fatty acid supplementation versus placebo, for primary prevention of cardiovascular events in people with diabetes
    Acronym: DRN 023 (ASCEND)
    Recruitment Site: Cardiff and Vale University Health Board
    Investigator: 
    Contact Details: 

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  • Title: Clinical Proof-of-Principle Trial in Adult Subjects with Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of NNC0114-0006 and Liraglutide on Preservation of Beta-cell Function
    Acronym: DIAB 3796
    Recruitment Site: University Hospital of Wales
    Investigator: Prof C Dayan
    Contact Details: 

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  • Title: DRAKO - An observational study to assess the effectiveness of intravitreal aflibercept in routine clinical practice in patients with visual impairment due to diabetic macular oedema (DMO)
    Acronym: DRAKO Non-Interventional Study
    Recruitment Site: University Hospital of Wales
    Investigator: 
    Contact Details: 

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  • Title: Exploration of the Peripheral Immune System in Subjects with New Onset Type 1 Diabetes (NOT1D)
    Acronym: NOT1D
    Recruitment Site: University Hospital of Wales
    Investigator: Prof C Dayan
    Contact Details: 

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  • Title: Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk
    Acronym: FOURIER
    Recruitment Site: Synexus Clinical Research Centre; Wales Heart Research Institute
    Investigator: Dr H Thomas
    Contact Details: 

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  • Title: Randomized EValuation of the Effects of Anacetrapib through Lipid-modification. A large-scale, randomized placebo-controlled trial of the clinical effects of anacetrapib among people with established vascular disease
    Acronym: REVEAL.
    Recruitment Site: University Hospital of Wales
    Investigator: Dr I McDowell
    Contact Details: 

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Research Centre/s

Institute of Molecular & Experimental Medicine
Cardiff University School of Medicine
University Hospital of Wales
Heath Park
Cardiff CF14 4XN

T: 02920 646710
E: diabetesresearch@cardiff.ac.uk
Research Nurse: 07816 240299

R & D Contact:

T: 02920 745339
E: research.development@wales.nhs.uk