Heath and Care Research Wales Supported Studies

 

The Diabetes Research Group Swansea Laboratory is providing lab support to:

 

The CLOuD Study

Closed Loop from Onset in type 1 Diabetes - ‘CLOuD’ Assessing the effect of closed loop insulin delivery from onset of T1DM in youth on residual beta-cell function versus standard insulin therapy

  • NIHR EME funded study
  • Multicentre study aiming to recruit approximately 100 participants
  • Newly diagnosed with T1DM and aged less than 18
  • Each participant in study for 2 years (plus 1 year extension)

 

The Diabetes Research Group Swansea Laboratory is

  • providing sample collection equipment (tubes, labels, lab manuals etc)
  • Organising periodic frozen sample collection from sites using courier service
  • Analysing HbA1c (every 3 months) and C-peptide and glucose from MMTT (every 6 months)

 

Find out more about the study http://cloud.mrl.ims.cam.ac.uk/

 

The USTEKID Study

USTEKID study Phase II multi-centre, double-blind, randomised trial of Ustekinumab in adolescents with new-onset type 1 diabetes to determine the efficacy of Ustekinumab for preserving Mixed Meal Tolerance Test (MMTT) stimulated 2-hour insulin C-peptide area under the curve (AUC) at week 52 as compared to placebo.

  • NIHR EME funded study
  • Multicentre study aiming to recruit approximately 72 participants
  • Newly diagnosed with T1DM and aged less than 18
  • Dosed within first 100 days of diagnosis

 

Diabetes Research Group Swansea Laboratory is

  • measuring eligibility screening samples for beta-cell autoantibodies and MMTT C-peptide levels
  • Batch analysing additional autoantibody samples, HbA1c, MMTT samples and dried blood spot C-peptide levels

 

Find out more about the https://www.type1diabetesresearch.org.uk/current-trials/ustekid/