Prediabetes

 

The Prediabetes & Obesity Research theme encompasses translational research from basic to clinical science, clinical trials and population health. The group has also built on collaborations within Psychology and the NHS to foster research. Members of the group play an active role in public, industry and professional engagement.

 

Areas of Research interest

  • Fat Biology:  This work focuses on the role visceral (abdominal) fat plays in the pathogenesis of Type 2 diabetes and its complications. Areas of interest include examining the effects of adipokines, visceral samples (ex-vivo) and adipose cell lines on inflammation, oxidative stress and insulin resistance. 
  • Cardiovascular & Adipose Genetics:  This work examines the role that genetic variation plays in determining genotypic and phenotypic characteristics associated with diabetes, obesity and associated complications. 
  • Metabolic Surgery & Diabetes Outcome: This work has focused on the role that metabolic surgery (bariatric surgery) has on insulin-glucose homeostasis, inflammation and vascular function. More recent work also examines the effects on exercise and physiological parameters relating to exercise physiology. 
  • Obesity, Metabolic Surgery & Psychological Function:  This work examines the contribution of Psychological factors on obesity and the outcomes from bariatric surgery. In addition the group has also had an interest in the effects of metabolic surgery on neurological outcomes including intracranial hypertension. 
  • Prediabetes & Diabetes Risk:  Work within this area examines risk tools and biochemical and genetic predictors of risk associated with the development of abnormalities in insulin and glucose homeostasis. Close collaboration has existed in previous years with industry examining risk stratification in the workplace. 
  • Clinical Trials:  The group is actively involved in Phase 3 trials examining new therapies being developed for the treatment of obesity.

 

Key Publications

View the research themes key publications here